1.Cobalt chloride is added in fermentation medium of ———production
(a) Citric acid
(c) Cyanocobalamin
(b) Lactic acid
(d) Riboflavin
Answer:(c) Cyanocobalamin
2.In recovery amylase is precipitated by ——–
(a) Cold acetone
(c) Cold isopropanol
(b) Cold ethanol
(d) All of the above
Answer:(d) All of the above
3.————-is the by-product in streptomycin fermentation
(a) Vit-A
(c) Vit-B1
(b) Vit-C
(d) Vit-B12
Answer:(d) Vit-B12
4.Which of the following antibiotic is act against Gram positive microbes
(a) Penicillin
(c) Chloramphenicol
(b) Streptomycin
(d) Amikacin
Answer:(a) Penicillin
5.Ames test is use to detect——–
(a) Mutations in DNA
(b) Purity of product
(c) Efficacy of Product
(d) Toxicity in Product
Answer:(a) Mutations in DNA
6.Saccharomyces cerevisiae is used in —— fermentation.
(a) Antibiotic
(b) Ethanol
(c) Citric acid
(d) L-Lysine
Answer:(b) Ethanol
7.The principle media used in ethanol fermentation is ——
(a) Black strap molasses
(b) Pepton
(c) Nitrogenous compound
(d) none of the above
Answer:(a) Black strap molasses
8.Geo bacillus stearothermophilus is used in the validation of ——
(a) Water Bath
(b) Autoclave
(c) Pasteurizer
(d) Tyndalize
Answer:(b) Autoclave
9.Seed lot system is used for the production of ——
(a) Vaccine
(b) Ethanol
(c) Antibiotic
(d) Vitamin
Answer:(a) Vaccine
10.The homo fermentative lactic acid producers is/are——-
(a) Lactobacillus Casey
(c) Streptococcus lactis
(b) Lactobacillus leichmannii
(d) All of the above
Answer:(b) Lactobacillus leichmannii
11.A biological assay use to assess the mutagenic potential of a Pharmaceutical product is ———
(a) Antibiotic assay
(b) Toxicity test
(c) Sterility test
(d) Ames test
Answer:(d) Ames test
12.Which of the following media is used for sterility test
(a) MacConkey’s medium
(b) Nutrient medium
(c) Ashby’s agar medium
(d) Fluid thioglycollate medium
Answer:(d) Fluid thioglycollate medium
13.The process by which new drug is created is ———
(a) Licencing
(b) R&D
(c) Manufacturing
(d) Marketing
Answer:(b) R&D
14.In sterility .test, the incubation period is –
(a) 24 hours
(b) 4 days
(c) 14 days
(d) 10days
Answer:(c) 14 days
15.——–test is use to assess the safety of industrial product
(a) Toxicity test
(b) Sterility test
(c) Ames test
(d) Ronald test
Answer:(a) Toxicity test
16.The most common organism For lactic acid production is ———
(a) Lactobacillus casei
(b) Escherichia coli
(c) Lactobacillus delbrueckii
(d) Aspergillus Niger
Answer:(c) Lactobacillus delbrueckii
17.The most commonly used microorganism in alcohol fermentation is——-
(a) Aspergillus niger
(b) Bacillus subtilis
(c) Saccharomyces cerevisiae
(d) Escherichia coli
Answer:(c) Saccharomyces cerevisiae
18.Ethanol is produced by microbial fermentation of ——–
(a) Proteins
(b) Sugars
(c) Lipids
(d) Nucleic acids
Answer:(b) Sugars
19.Antibiotic penicillin is active against——-
(a) Gram positive organisms
(b) Viruses
(c) Gram negative organisms
(d) Fungi
Answer:(a) Gram positive organisms
20.The commercial organism used for citric acid production is ——-
(a) Penicillium Notatum
(b) Staphylococcus aureus
(c) Aspergillus Niger
(d) Aspergillus Flavus
Answer:(c) Aspergillus Niger
21.—–is one of the suitable method for validation of HEPA Fillers
(a) Heat penetration studies
(b) Bowie Dick test
(c) Both (a) & (b)
(d) Anemometer
Answer:(d) Anemometer
22.Salmonella Typhimurium is used in test
(a) Toxicity
(b) Sterility
(c) Ame’s
(d) Dop
Answer:(c) Ame’s
23.Brevi bacterium flavum is also used in the production of ——-
(a) L. Lysine
(b) L. glutamic acid
(c) Amylase
(d) Valine
Answer:(b) L. glutamic acid
24.——methods are not used in environmental monitoring
(a) Sponge & Swabs
(b) Air testing and settle plates
(c) Membrane filter test
(d) Direct contact.
Answer:(c) Membrane filter test
25.GMP stands for ——-
(a) Good manufacturing process
(b) Good manufacturing practice
(c) Good marketing process
(d) General manufacturing practice
Answer:(b) Good manufacturing practice
26.Saccharomyces cerevisiae is a fermenting Yeast .——–
(a) top
(b) bottom
(c) top and bottom
(d) submerged
Answer:(a) top
27.——-is a typical facility for work with a low hazards agents
(a) BL – 1
(b) BL – 2
(c) BL – 3
(d) BL – 4
Answer:(a) BL – 1
28.Citric acid production is possible by —–method.
(a) Submerge Culture
(b) Surface Culture
(c) Shallow pan
(d) all of the above
Answer:(b) Surface Culture
29.The —–constitute a large group of enzymes.
(a) Vit B12
(b) Amylase
(c) L.lysine
(d) Citric acid
Answer:(b) Amylase
30.The best medium for the production of penicillin is——-
(a) Nutrient Agar
(b) Corn steep liquor
(c) Sulfite waste liquor
(d) Whey
Answer:(b) Corn steep liquor
